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pentobarbital will decrease the level or influence of lonafarnib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is usually a sensitive CYP3A4 substrate. Coadministration with solid or moderate CYP3A4 inducers is contraindicated.
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pentobarbital will reduce the level or outcome of tramadol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Monitor. Decreased AUC of tramadol as well as active metabolite (O-desmethyltramadol) when coadministered with sturdy CYP3A4 and CYP2B6 inducers
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pentobarbital will reduce the extent or outcome of capivasertib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Potent or moderate CYP3A inducers reduce capivasertib publicity, which may decrease efficacy.
pentobarbital will minimize the extent or result of elbasvir/grazoprevir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. The therapeutic impact of elbasvir/grazoprevir might be reduced if coadministered with strong CYP3A inducers and is particularly hence contraindicated.