pentobarbital will reduce the extent or influence of larotrectinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism.pentobarbital will decrease the level or influence of lonafarnib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Lonafarnib is usually a sensitive CYP3A4 substrate. Coadministration with solid or mod